The differences between Brotherhood and the original FMA anime is vast and surprising. I certainly liked Brotherhood more than the original and from the information I have read, it also follows the manga far closer in story line.
The story of Brotherhood and also the original FMA weaves an interesting mythos about a power known as Alchemy, which in the anime has replaced most of science as we know it with this supernatural power.
There are moments in the story of both animes that will tear your heart in two. You will be drawn into the plot and follow Edward and Alphonse Elric until the end and you will agonize with them, cry with them, laugh with them, become so angry that you want them to cut loose and just kick some ass.
The story really is that compelling.
If you haven’t seen FMA or Brotherhood then you really should. You will have action, mystery and suspense. You will have tears and laughter too, as I said.
The Journey of the Elrics wraps up quite nicely in the end, yet leaves some mystery too. I encourage you to take a look into these stunning shows.